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Basic Principles:        

Serum albumin (HSA) is the main component of the blood transport system in the human organism. It provides the transport of fatty acids and other physiologically important compounds, as wells as toxins and several pharmaceuticals. The transport of these substances is due to by conformational changes of the albumin.

The variety of albumin function for all transport stages is based on the high conformational flexibility of this protein. In the case of cancer, several specific proteins are present in the blood circuit in very low concentrations. These proteins preferentially accumulate to serum albumin and influence the albumin function by changing its conformation. Under pathological conditions there are several modifications of conformation mobility of albumin, resulting in a modified transport and altered detoxification characteristics (Lowenthal et al., 2005). A comparison of the structure of normal albumin and albumin saddled with cancer proteins reveals a dramatic extent of conformational changes that occur when fatty acids bind.

These modified binding characteristic can be detected by Electron Spin Resonance Spectroscopy (ESR). A spin labeled fatty acid is added to the serum and is analyzed with ESR spectroscopy. These reporter molecules bind to different albumin binding sites, therefore the ESR spectra shows different components.

The resulting ESR sprectrum consists of four distinct components:

Out of theses components an integral discrimination function (DR) is calculated. Usualy the DR is sufficient to give reliable diagnosis. In case of a borderline DR, additional parameters like binding-, transport- and detoxification properties are taken into consideration for a more precise diagnosis. In case of DR-value < 1 the albumin conformation has changed and an  active malignant process has taken place. If the DR-value is > 1 no aktiv tumor growth exists. A high risk of active tumor growth is indicated for DR values in the threshold range from 1 to 1.2.

The MMS-Test by ESR analysis offers a fast and reliable method for early cancer detection in the human body with a high sensitivity and specificity (90 % sensitivity & 90% specificity in studies).